![]() ![]() According to UK Government statistics, over 5 million people are unaware they have high blood pressure yet it affects more than 1 in 4 adults and is one of the biggest risk factors for premature death and disability in the UK. ![]() They're both measured in millimetres of mercury (mmHg).Īs a general guide, high blood pressure (or hypertension) is considered to be 140/90mmHg or higher and ideal blood pressure is considered to be between 90/60mmHg and 120/80mmHg A blood pressure reading between 120/80mmHg and 140/90mmHg could mean you're at risk of developing high blood pressure if you don't take steps to keep your blood pressure under control. The diastolic pressure (lower number) is the resistance to the blood flow in the blood vessels. The systolic pressure (higher number) is the force at which your heart pumps blood around your body. The researchers believe that these particular compounds are, at least in part, responsible for the reduction.īlood pressure is recorded with two numbers. The greatest improvement in systolic blood pressure occurred when the phenolic acids, protocatechuic and vanillic, within the cherry concentrate reached their peak levels in the plasma. Interestingly, those participants with blood pressure levels at the higher end of the scale saw the most benefit. Past studies have shown that a reduction of between 5-6 mmHg over a sustained period has been associated with a 38% reduced risk of stroke and 23% reduced risk of coronary heart disease. The researchers found that the participants who were given the cherry concentrate saw a peak reduction in their blood pressure of 7 mmHg in the three hours after consuming the drink. This reduction is comparable to the level achieved by anti-hypertensive medication. Arterial blood pressure will be recorded with a transducer located at heart level (TruWave, Edwards Lifesciences, Nyon, Switzerland).The findings, which are published in The American Journal of Clinical Nutrition, found that men with early signs of hypertension (high blood pressure) saw a 7% reduction in blood pressure after drinking a concentrated Montmorency cherry juice (CherryActive) when compared to drinking a fruit-flavoured cordial. The mean depth for Doppler signals was 51 ± 3 mm. 1982) and will be secured with an adjustable headset (DiaMon, Compumedics DWL). A 2 MHz Doppler probe was positioned over the right middle cerebral artery using previously described search techniques (Aaslid et al. 2007).īlood velocity in the middle cerebral artery (MCAV) will be determined using transcranial Doppler sonography. Each sensor contains two detectors located at 3 and 4 cm from the emitting source that detect oxygenated and deoxygenated states of Hb to estimate regional O2 saturation based on internal algorithms (Rasmussen et al. The sensors alternately emit near-infrared light at wavelengths of 730 and 810 nm. The sensors will be secured to the skin using double-sided adhesive tape and shielded from ambient light using an elastic bandage. Two near-infrared sensors will be placed on the skin over the right and left prefrontal cortex region of the forehead, and the signals were averaged to determine cerebral oxygenation. After a minimum of 2 weeks, participants will be asked to return to the lab and repeat the procedure with the other drink.Ĭerebral oxygenation will be assessed using near - infrared spectroscopy. ![]() No additional food or drink will be provided during the study period except for low-nitrate mineral water. The relevant drink will then be provided and blood samples and blood flow measures will be taken at hourly intervals (1, 2, 3, and 5h). A cannula will be inserted and baseline blood samples obtained, baseline measures of cerebral blood flow will be examined using near infrared spectroscopy and its effect on cognitive function using a cognitive demand battery. Participants will then attend the first study day following an overnight fast. Study days: Forty - eight hours prior to each study day, participants will begin dietary restrictions. Training will be given on the cognitive tasks and familiarisation with the study procedures will be provided. During the initial visit participants will be provided with written informed consent and screened with regards the study exclusion/inclusion criteria. ![]() The first of these will be an initial screening/training visit, within 14 days of the first active study visit. Why Should I Register and Submit Results?Įach participant will be required to attend the laboratory on three occasions. ![]()
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